Starting from the south of Salzburg you follow route B 159 Anif - Niederalm - Hallein (saltmines) and up from Hallein to Gollingalong the Salzach River to Werfen, passing the famous Giant Ice Caves of Werfen (a visit would take at least 3 hours) and following the Salzach River to Bischofshofen - Schwarzach (now B 311 along tue Salzach river) to Bruck an der Glocknerstraße.
Turn left to Großglockner Hochalpenstraße (toll .- Euro). 30 Kilometers later after 36 turnings and more than 2.500 Meters elevation you see the high alpine Region of Austrias highest mountain Großglockner (3.798 m) with lots of snow even in summer and a impressive view of the Pasterzen Glacier.
Even if you start with warm temperatures in the valley, be aware of Minus - degrees up there !
The way back you go via Bruck to Zell am See - Saalfelden to Bad Reichenhall.
If you are good in time until Bad Reichenhall , turn right 9 Kilometers before Reichenhall to Schneitzlreuth on to the Deutsche Alpenstraße to Berchtesgaden (few minutes to Königssee, Kings Lake) and carry on to Markt Schellenberg - Grödig - Anif - Salzburg.On this last part of your trip you can either go up to Eagles nest (4 Kilometers out of Berchtesgaden on Obersalzberg and/or celebrate a final loup on the 20 kilometerRossfeldstrasse (toll 3,50) up to 1.500 meters with fantastic panorama views to the Berchtesgaden mountains and the Austrian Salzach Valley , where you started in the morning.
If you do the whole Trip backwards and start early enough ( 07:00 or 08:00 am), you have on the way back from Großglockner through Salzach Valley the opportunity to visit the worlds probably largest ice caves, the Giant Ice Caves of Werfen